Transaction Creates a Leading Vaccine Company and Maximizes Value for Aviragen Stockholders

Updated Investor Presentation Filed with Securities and Exchange Commission and Posted to Aviragen
Website

ATLANTA, Jan. 11, 2018 (GLOBE NEWSWIRE) — Aviragen Therapeutics, Inc. (NASDAQ:AVIR) today reiterated its support of the pending
merger with Vaxart, Inc., which was unanimously approved by the Aviragen Board of Directors.

In reiterating its support for and recommending that Aviragen stockholders vote in favor of the proposed merger with Vaxart at
the special meeting of stockholders on February 6, 2018, the Company notes that:

  • The transaction maximizes the value of Aviragen: Based on the valuations of a selected set of publicly
    traded vaccine companies, Vaxart’s estimated potential valuation prior to the merger is approximately $158 million. Based on the
    ownership structure in the transaction, this would imply a value of the combined company at $264 million, with the potential
    value of Aviragen in the merger being $106 million, a significant improvement in value compared to Aviragen’s current market
    capitalization of approximately $23 millioni.
  • Aviragen stockholders will have the opportunity to participate in the significant upside potential of the
    merger:
    The combined company will be focused on developing Vaxart’s oral recombinant vaccines and Aviragen’s
    direct-acting antivirals to treat infections that have limited therapeutic options. Vaxart’s oral tablet vaccines have the
    potential to become major products in the worldwide vaccine market. In a head-to-head comparison with a leading injectable
    influenza vaccine, Vaxart’s oral tablet vaccine delivered clinical proof of efficacy and an excellent safety profile that
    significantly de-risks the platform. Further, the combined company will be well-financed to achieve value creating milestones
    that include efficacy data from Aviragen’s BTA074 HPV Phase 2 data, Vaxart’s Phase 2 norovirus vaccine data, and the filing of
    additional INDs for new programs. Together, Aviragen and Vaxart will be poised to create meaningful value for stockholders in the
    near- and long-term.
  • Aviragen’s Board conducted a thorough process that included an extensive review of strategic alternatives:
    The Company’s Board formed an independent transactions committee that evaluated a number of options, including a business
    combination or strategic merger, in-licensing clinical stage programs, acquisitions, liquidation or other transactions that would
    complement Aviragen’s current assets. Ultimately the Board – at the recommendation of the transactions committee – accepted
    Vaxart’s offer as Aviragen’s directors unanimously agreed that it was in the best interest of the Company’s stockholders.
    Aviragen notes that, compared to other unrealistic estimates that have been previously assumed by others, the realistic
    liquidation value of the Company was estimated at only $22.4 million – or $0.58 per share – as of October 31, 2017. More
    importantly, in a liquidation, there can be no assurances as to the actual amount or timing of available cash left to distribute
    to stockholders after paying debts, other obligations and setting aside funds for reserves.

EACH VOTE IS IMPORTANT – PLEASE VOTE FOR THE PROPOSED MERGER WITH VAXART TODAY

Each vote is extremely important, no matter how many or how few shares are owned. The affirmative vote of the holders of a
majority of the shares of Aviragen common stock properly cast at the Aviragen special meeting, presuming a quorum is present, is
required to approve the proposed merger. Aviragen shareholders of record at the close of business on January 2, 2018 are entitled
to vote at the special meeting. Please take a moment to vote FOR the proposals necessary to approve the proposed
merger today – by telephone, by Internet or by signing, dating and returning the proxy received with the proxy statement.

Stockholders who have any questions or need assistance voting their shares should contact Aviragen’s proxy solicitor, D.F. King
& Co., Inc., toll-free at (800)-967-5074.

Updated Investor Presentation Filed with SEC and Posted to Aviragen’s Website

Aviragen has filed an updated investor presentation with the U.S. Securities and Exchange Commission (“SEC”) in order to provide
all stockholders with additional information associated with the proposed merger with Vaxart. The presentation is available on the
SEC’s website at www.sec.gov and the investor relations section of the Company’s website at www.aviragentherapeutics.com.

Advisors

Stifel, Nicolaus & Company, Incorporated is acting as financial advisor to Aviragen, and Dechert LLP is serving as legal counsel
to Aviragen. Cooley LLP is serving as legal counsel to Vaxart.

About Aviragen Therapeutics

Aviragen Therapeutics is focused on the discovery and development of the next generation of direct-acting antivirals to treat
infections that have limited therapeutic options and affect a significant number of patients globally. It has three Phase 2
clinical stage compounds: BTA074 (teslexivir), an antiviral treatment for condyloma caused by human papillomavirus types 6 and 11;
vapendavir, a capsid inhibitor for the prevention or treatment of rhinovirus (RV) upper respiratory infections; and BTA585
(enzaplatovir), a fusion protein inhibitor in development for the treatment of respiratory syncytial virus infections. Aviragen
also receives royalties from marketed influenza products, Relenza® and Inavir®. For additional information, please visit www.aviragentherapeutics.com.

Aviragen Therapeutics® is a registered trademark. Relenza® is a registered trademark of GlaxoSmithKline Pharmaceuticals, Ltd.,
and Inavir® is a registered trademark of Daiichi Sankyo Company, Ltd.

About Vaxart

Vaxart is a clinical-stage company developing a range of oral recombinant vaccines based on its proprietary delivery platform.
Vaxart vaccines are administered using convenient room temperature-stable tablets that can be stored and shipped without
refrigeration and eliminate risk of needle-stick injury. Its development programs are oral tablet vaccines designed to protect
against norovirus, seasonal influenza and respiratory syncytial virus (RSV), as well as a therapeutic vaccine for human
papillomavirus (HPV), Vaxart’s first immuno-oncology indication. For more information, please visit www.vaxart.com.

Forward Looking Statements

This press release contains forward-looking statements about Aviragen Therapeutics, Inc. and Vaxart Inc., and their respective
businesses, business prospects, strategy and plans, including but not limited to statements regarding the estimated value of the
combined company; anticipated preclinical and clinical drug development activities, timelines and market opportunities; the
combined company being well-funded to advance its programs; and the combined company’s ability to generate near and long term value
for stockholders. All statements other than statements of historical facts included in this press release are forward looking
statements.  The words “anticipates,” “may,” “can,” “plans,” “believes,” “estimates,” “expects,” “projects,” “intends,”
“likely,” “will,” “should,” “to be,” and any similar expressions or other words of similar meaning are intended to identify those
assertions as forward looking statements.  These forward looking statements involve substantial risks and uncertainties that
could cause actual results to differ materially from those anticipated, including, without limitation: the risk that the conditions
to the closing of the merger are not satisfied, the failure to timely or at all obtain stockholder approval for the merger;
uncertainties as to the timing of the consummation of the merger and the ability of each of Aviragen and Vaxart to consummate the
merger; risks related to Aviragen’s ability to correctly estimate its operating expenses and its expenses associated with the
merger; risks related to the market price of Aviragen’s common stock relative to the exchange ratio; the ability of Aviragen or
Vaxart to protect their respective intellectual property rights; competitive responses to the merger; unexpected costs, charges or
expenses resulting from the merger; and potential adverse reactions or changes to business relationships resulting from the
announcement or completion of the merger. The vaccine candidates that Vaxart develops may not progress through clinical development
or receive required regulatory approvals within expected timelines or at all. In addition, future clinical trials may not confirm
any safety, potency or other product characteristics described or assumed in this press release and such vaccine candidates may not
successfully commercialized.  Additional factors that may cause actual results to differ materially from such forward looking
statements include those identified under  the caption “Risk Factors” in the documents filed by Aviragen with the Securities
and Exchange Commission from time to time, including its Proxy/Prospectus on Form S-4, Annual Reports on Form 10-K, Quarterly
Reports on Form 10-Q, and Current Reports on Form 8-K.  You are cautioned not to place undue reliance on these forward-looking
statements, which speak only as of the date of this press release. Except to the extent required by applicable law or regulation,
neither Aviragen nor Vaxart undertakes any obligation to update the forward-looking statements included in this press release to
reflect subsequent events or circumstances.

Additional Information About the Merger and Where to Find It

In connection with the proposed strategic merger, Aviragen and Vaxart have filed relevant materials with the Securities and
Exchange Commission, or the SEC, including a registration statement on Form S-4, as amended, that contains a prospectus and a joint
proxy statement. Investors may obtain the proxy statement/prospectus, as well as other filings containing important information
about Aviragen, Vaxart and the merger, free of charge at the SEC’s web site (www.sec.gov). In addition, investors and security
holders may obtain free copies of the documents filed with the SEC by Aviragen by directing a written request to: Aviragen
Therapeutics, Inc. 2500 Northwinds Parkway, Suite 100, Alpharetta, GA 30009, Attention: Corporate Secretary or delivered via email
to investors@aviragentherapeutics.com. Investors and security holders are urged to read the proxy statement/prospectus and the
other relevant materials before making any voting or investment decision with respect to the merger.

This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer
to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale
would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offering of
securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as
amended.

Participants in the Solicitation

Aviragen and Vaxart and their respective directors and officers and certain of their other members of management and employees
may be deemed to be participants in the solicitation of proxies from the stockholders of Aviragen in connection with the proposed
transaction. Information regarding the special interests of these directors and executive officers in the merger are included in
the proxy statement/prospectus referred to above. Additional information regarding the directors and executive officers of Aviragen
is also included in Aviragen’s Annual Report on Forms 10-K for the year ended June 30, 2017, filed with the SEC on September 1,
2017, and the Form 10-K/A filed with the SEC on October 20, 2017. These documents are available free of charge from the sources
indicated above.

Contacts

Mark Colonnese

Executive Vice President and Chief Financial Officer

Aviragen Therapeutics, Inc.

(678)
221-3381                                  

mcolonnese@aviragentherapeutics.com

Beth DelGiacco

Stern Investor Relations, Inc.

(212) 362-1200

beth@sternir.com

Kristian Klein

D.F. King & Co., Inc.

(212) 232-2247

Winnie Lerner / Nick Leasure

Finsbury

(646) 805-2855

i Based on Aviragen’s closing share price on January 11, 2018.

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